Follow-up projects

Below is an overview of the most significant follow-up projects that continue the scientific and research focus of the CarDia National Institute project and further build upon the results achieved during its implementation.

These projects make it possible to maintain the continuity of research activities, expand upon the knowledge gained, and apply it to other areas of development, clinical practice, and interdisciplinary collaboration. At the same time, they provide an important financial framework for continuing scientific work, as funds designated for financing the research itself are no longer available during the project’s sustainability period.

Follow-up projects thus ensure not only the further professional development of topics initiated in the National CarDia Institute project, but also stable conditions for the continuation of the team’s research and innovation activities.

Project Title
Link
Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors as new pharmacological tools in the prevention of organ damage
Modulation of senescence as a potential therapeutic approach to reducing the risk of kidney damage in patients with obesity and type 2 diabetes mellitus
Protection of endothelial cells and promotion of islet graft engraftment using vascular growth factors
Pericoronary adipose tissue—an active or passive role in the development of atherosclerosis?
Development of a telemedicine application for managing nutritional support and physical activity as part of prehabilitation prior to planned solid organ transplantation
The role of adipose tissue and muscles in regulating metabolic flexibility: Investigating new predictors of successful lifestyle intervention in obese patients
Biomimetic vascular graft for low flow rates enabling physiological pulse wave transmission
Identification and characterization of genetic causes of hereditary forms of tubulointerstitial kidney disease
The effect of partial HIF-1 alpha deficiency on the development of heart failure with preserved ejection fraction: new pharmacological therapies.
A multi-omics platform for identifying biological correlates of disease and developing new diagnostic, preventive, and therapeutic approaches
Bioorthogonal reactions of 1-alkyl-1,2,4-triazine salts (GA24-10829S)
Effective Targeted Therapies: Development and Commercialization of Modern Approaches to Antibody Conjugation (TQ15000018)
Ultraviolet Photodissociation Mass Spectrometry for Advanced Structural Analysis of Lipids (GA26-20832S)
The Role of Epicardial Fat in the Etiopathogenesis of Atrial Fibrillation
The Effect of Bariatric Surgery and Pharmacological Treatment of Obesity on Muscle Mass and Function: A Comparative Study in Patients with and without Type 2 Diabetes - ARNOLD
Metabolic flexibility of adipose tissue as a predictor of bariatric surgery efficacy
Innovative coatings for dental applications based on microdomains with encapsulated silver nanoparticles providing permanent and/or light-induced bactericidal protection
New Strategies For The Early Diagnosis, Risk Stratification and Co-management of Familial Hypercholesterolemia
Effect of Breastfeeding on Lipid Profile and Cardiovascular Risk Markers in Women With Familial Hypercholesterolemia
Czech Infrastructure for Integrative Structural Biology (CIISB)
HE INFRA Fragment
HE INFRA Imagine
HE Molecular Dynamics for Structure-based Biology
Bacterial extracellular vesicles as mediators of intercellular communication in infective endocarditis
These follow-up projects focus on three key areas of the current "epidemic" of lifestyle-related diseases—obesity, diabetes, and cardiovascular disease.

Obesity

Obesity is defined as weight gain above the normal limit due to excessive accumulation of adipose tissue in the body. Obesity is determined by the body mass index (BMI), which is calculated as the ratio of body weight in kilograms to the square of body height in metres. The increasing prevalence of obesity is a major health problem in virtually all developed countries of the world. In the Czech Republic, more than half of the adult population is overweight (defined as a BMI between 25-29.9 kg/m2 ) or obese (BMI > 30 kg/m2 ), and the number is increasing.

Diabetes mellitus

Diabetes mellitus is a disease caused by a long-term increase in blood glucose (sugar) levels. If diabetes is not adequately treated, elevated glycaemia levels lead to serious complications, especially increased risk of cardiovascular disease (heart attack, stroke), reduced life expectancy, and damage to eyesight, nerves and kidneys.

Cardiovascular disease

Although cardiovascular disease mortality rates are steadily declining, they are still the most common cause of death in most European countries, including the Czech Republic, where they are responsible for half of all deaths. Yet the Czech Republic lags far behind Western Europe. Compared to France, the death rate from these diseases is almost three times higher.