Dominika Sojáková, a PhD student under the supervision of Assoc. Prof. Michal Dubský, MD, PhD, has published—together with him and other co-authors—the results of a unique long-term study in the prestigious journal Stem Cell Research and Therapy. The study focuses on the efficacy of autologous cell therapy (ACT) in patients with diabetes and chronic limb-threatening ischemia (CLTI).
Over the course of this 16-year prospective study, ACT was administered to 107 patients who were not eligible for standard revascularization procedures. The therapy involved the application of bone marrow-derived stem cells directly into the affected limb. The results showed a 68.2% limb salvage rate, confirming the effectiveness of ACT in this high-risk patient population.
The study also identified key factors that negatively impacted treatment success—namely the use of immunosuppressive therapy, advanced femoropopliteal disease (GLASS FP score), and the presence of clinical signs of infection.
The publication is available in open access here:
dana.hruskova@ikem.cz
